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Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   Spring 2002 , Volume 19 , Number 61; Page(s) 56 To 60.
 
Paper: 

THE PREVENTIVE EFFECT OF HEPARIN OF STRICTURE FORMATION AFTER CAUSTIC ESOPHAGEAL BURNS

 
 
Author(s):  NAZEM A., SADEGHZADEH SH., GHOREISHI M.M.
 
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Abstract: 
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Preventing thrombus formation after caustic esophageal ingestion has been proposed to have beneficial effects.
Therefore, an experimental study was carried out to investigate the effects of heparin on the esophagus after caustic burns.
Caustic esophageal burns were produced in rats by irrigation with 50% NAOH and 0.5% cl (ingredients of whitex). Rats were devided into four groups as follows: group A: Animals with esophageal burns, received subcutaneous heparin treatment and underwent autopsy 48 hour after caustic injury. group C, animals with esophageal burns, received subcutaneous heparin treatment for 7 days and underwent autopsy 28 days after caustic injury. group D, animals with esophageal burns, received placebo and underwent autopsy 28 days after caustic injury. Histopathologic evaluation was performed in all groups and esophageal strictures were evaluated by circumferences diameter of the burned segments.
Congestion and inflammation was encounter in all groups of animals. The submucosal venules and arterioles were patent in 30% of group A animals. Submucosal vascular thrombosis was encountered in all group B animals. Esophageal strictures did not develop in any of group C animals, but varying degree 01 esophageal stenosis were encountered in all animals of group D. The circumferences of the burned segment have been narrowed to 8 :t 0.1mm in group D. collagen deposition was obvious in 20% of group D rats.
Although heparin has ameliorating effects on preventing thrombus formation. But effect of heparin on stricture formation in this study was not significant in statistical analysis (p>0.05).

 
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