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Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   Spring 2002 , Volume 19 , Number 61; Page(s) 13 To 17.
 
Paper: 

COMPARATIVE EVALUATION OF GENTAMYCIN AND CEFOTAXIM EFFICACY IN CHILDREN'S PYELONEPHRITIS

 
 
Author(s):  AJOUDANI T.S., GHAZAVI M.R.
 
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Abstract: 
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Urinary tract infection (UTI) is one of the common and important infectious diseases in pediatrics, which should be treated promptly with appropriate drug, because of potential sequel and subsequent complication. but usually we don't know the bactrial suseptibility at the beginning of the treatment. It has been recommended to begin with a broad spectrum antibiotic including Cefotaxim or Gentamycin. We were going to know the escope of efficacy of these drugs and compare them together, and this would help to choose an appropriate selection of drugs for primary treatment of children's pyelonephritis.
In a randomized clinical trial we evaluated the efficacy of cefotaxim versus Gentamycin in all 77 hospitalized children with UTI and fever in Isfahan-Alzahra Hospital during two years (1999-2000). The Criteria for efficacy of treatment were urine sterilization, and be afebrile after 48 hours, and negative serum CRP after 96 hours of treatment. Fisher Exact test was used for difference exposure.
Treatment were effective in 97% of patients treated with Gentamycin and 100% of those treated with Cefotaxim. Using Fisher Exact test, made no difference between these two groups. (P=0.5)
Cefotaxim or Gentamycin could be recommended as an effective treatment for children's pyelonephritis in our situation but because of low cost and high accessibility sometimes Gentamycin is better than the other.

 
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