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Paper Information

Journal:   IRANIAN JOURNAL OF TOXICOLOGY   FALL 2012 , Volume 6 , Number 18; Page(s) 699 To 703.
 
Paper: 

BIOTECHNOLOGICAL REDUCTION OF TOBACCO (NICOTIANA TABACUM L.) TOXICITY

 
 
Author(s):  SATTAR SAMANE, ASGHARI GHOLAMREZA*, EHSANPOUR ALI AKBAR
 
* ISFAHAN PHARMACEUTICAL SCIENCES RESEARCH CENTER, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background
Nicotiana tobacco contains large amounts of alkaloid nicotine. Tobacco plant is used for smoking and causes many health problems since it is high in nicotine which is one of the widely-recognized toxic compounds with serious side effects for different body organs. Reducing nicotine content of this plant is a way to reduce its health hazards in cigarette smokers. Utilizing the new methods of genetic engineering can modify nicotine levels in the plant. In this study, through transferring the blocking gene, the pathway of nicotine biosynthesis was blocked to produce transgenic tobacco with low levels of nicotine.
Methods
Transgenic plants carrying T DNA, and non-transgenic plants were grown on MS medium. Then their leaves were dried and powdered. The plants were extracted with alkali solution. Eventually, the nicotine content of the extract were analyzed using GC.
Results
The analysis of extracts showed a reduction in the nicotine content of the transgenic plant (contain T-DNA) in comparison with non-transgenic plants.
Conclusion: Tobacco with lower nicotine reduction can reduce the toxic effects of smoking on smokers and can facilitate withdrawal from it.

 
Keyword(s): NICOTINE, NON-TRANSGENIC TOBACCO, TOBACCO, TOXICITY, TRANSGENIC
 
References: 
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