Introduction: With regard to the interactions between brain and spleen, in this research, the effect of splenectomy on PTZ-induced epilepsy in Wistar rats was studied.
Methods: In this study, 48 male and female wistar rats were used in 3 groups. Experimental groups for each of the two sexes included the negative control, positive control and splenectomy. Negative controls did not undergo surgery. The incision was created in the positive control group, but the spleen was not removed. The spleen was removed in splenectomy group. After seven days, PTZ was injected and the initiation time of different convulsive stages in terms of seconds and score of seizures in the three groups with the same gender were compared using one-way ANOVA.
Results: Second stage of convulsive seizures in the splenectomy group of male rats in comparison with control groups decreased significantly. Fourth stage of seizure in female splenectomized rats in comparison with negative control group decreased significantly. Also score terms of seizures in both male and female rats were not significantly different in the three groups.
Conclusion: Splenectomy intensifies PTZ-induced seizures in Wistar rats.