In this paper, plastic flow behavior and micro structural evolution of Ti-6Al-4V alloy in temperature range of 750-1050oC and strain rate range of 0.001-0.1 (S-1) in isotherm compression condition were investigated. The purpose was to estimate activation energy of globularization of lamellar structure and analyze this process kinetically. True Stress-strain curves obtained at the temperatures below 950oC indicate a limited amount of flow softening imputed to a dynamic recrystallization occuring at about 950oC. In contrast, at higher temperatures, the flow stress increases linearly with plastic strain until at temperatures about 1015oC where flow stress becomes nearly independent of the temperature. By analyzing flow stress data via Zener-Hol-lomon and sellars equation, Q activation energy of dynamic recrystallization was estimated and structural equation of plastic flow was obtained, whixh were comparable to results raeched by other investigators.