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Paper Information

Journal:   IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)   DECEMBER 2011 , Volume 10 , Number 4; Page(s) 237 To 242.
 
Paper: 

IN VITRO SOLUBLE CD30 LEVELS IN PATIENTS WITH CHRONIC STABLE CORONARY ARTERY DISEASE

 
 
Author(s):  MAHMOUDI MOHAMMAD JAFAR, HEDAYAT MONA, REZAEI NIMA, SABOOR YARAGHI ALI AKBAR, MAHMOUDI MARYAM*
 
* DEPARTMENT OF NUTRITION AND BIOCHEMISTRY, SCHOOL OF PUBLIC HEALTH, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 
The CD30 antigen seems to play a costimulatory role in maintaining the physiological balance between T-helper (Th) 1/Th2 immune responses. In this study, plasma andin vitro soluble CD30 (sCD30) secretion was investigated in patients with coronary artery disease (CAD) as a plausible marker of dysregulated immune response.
Twenty one patients with angiographically confirmed CAD and 31 healthy controls took part in this study. The levels of the activation marker sCD30 were determined in plasma and phytohaemagglutinin (PHA) -stimulated and unstimulated peripheral blood mononuclear cell cultures by ELISA.
Plasma sCD30 levels did not differ significantly between the patients and controls.
However, spontaneous sCD30 secretion was significantly lower in patients with CAD compared to controls (p<0.001). The soluble CD30 levels were significantly increased in the supernatant of PHA-stimulated PBMCs compared to unstimulated cultures in both groups of patients and controls (p<0.001). PHA-stimulated sCD30 secretion was found to be lower in patients compared to controls; however, the difference was not statistically significant.
Plasma sCD30 levels were not statistically different in patients with chronic stable CAD, a well-known Th1-mediated disease, compared to controls; whereas decreased spontaneous and PHA-stimulated sCD30 secretion in patients with CAD might indicate the progressive shift towards a Th1 immune response.
 
Keyword(s): CORONARY ARTERY DISEASE, SOLUBLE CD30, T-HELPER
 
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