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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   APRIL 2012 , Volume 15 , Number 4; Page(s) 247 To 248.
 
Paper: 

LIVER INVOLVEMENT IN MELAMINE-ASSOCIATED NEPHROLITHIASIS

 
DOI: 

012154/AIM.0015

 
Author(s):  HU PENG*, WANG JING, ZHANG MIN, HU BO, LU LING, ZHANG CHUAN RONG, DU PENG FEI
 
* DEPARTMENT OF PEDIATRICS, THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIVERSITY, HEFEI 230022, ANHUI PROVINCE, CHINA
 
Abstract: 

It is currently believed that melamine ingestion can lead to insoluble crystals in an animal's urinary system with subsequent physical obstruction or bladder carcinoma. However, whether melamine can cause injury of other tissues and organs in humans is yet unknown. In this study, we encountered 3 affected children with liver lesions, 2 males and 1 female, and detailed their clinical characterizations. Their ages were respectively 2, 6, and 10 months. Among the 3 patients with liver lesions, only 1 exhibited symptoms of gradual progressive jaundice, abdominal distention, hepatic intumesce, and bilirubin abnormality; the other 2 were asymptomatic. The mechanism associated with liver lesion may, at least in part, be due to physical deposition and blockage of the biliary tract system. Disturbance of the acid-base equilibrium may be another reason that accelerates stone formation in human tissues.

 
Keyword(s): ALANINE AMINOTRANSFERASE, CHILD, LIVER LESION, MELAMINE, NEPHROLITHIASIS, ULTRASONOGRAPHY
 
References: 
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