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Paper Information

Journal:   IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)   MARCH 2011 , Volume 13 , Number 3; Page(s) 187 To 191.
 
Paper: 

A PHASE II STUDY OF DOCETAXEL, CISPLATIN AND 5- FLUOROURACIL (TPF) IN PATIENTS WITH LOCALLY ADVANCED HEAD AND NECK CARCINOMAS

 
 
Author(s):  ANSARI M., OMIDVARI S., MOSALAEI A., AHMADLOO N., MOSLEH SHIRAZI M.A., MOHAMMADIANPANAH M.*
 
* NEMAZEE HOSPITAL, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN, POSTCODE: 71936-15311
 
Abstract: 
Background: The combination of cisplatin and 5-fluorouracil (PF) is currently considered a standard and effective regimen for the treatment of advanced head and neck carcinomas. The aim of this study was to evaluate the efficacy and safety of docetaxel, cisplatin and 5-fluorouracil (TPF) in patients with unresectable head and neck carcinomas.
Methods: Forty-six patients with previously untreated non-metastatic stage IV head and neck carcinomas were enrolled.
All patients received three cycles of induction chemotherapy with docetaxel (75 mg/m2), cisplatin (40 mg/m2) (days 1-2), and 5-FU (500 mg/m2, days 1-3), repeated every 21 days. Following induction chemotherapy, all patients underwent concurrent chemoradiotherapy using weekly cisplatin (30 mg/m2) and a median total dose of 70 Gy was delivered. Clinical response rate and toxicity were the primary and secondary end-points of the study.
Results: There were 31 men and 15 women. All patients had non-metastatic stage IV (T2-3N2-3 or T4N0-3) of disease. Overall and complete response rates were 74% and 24% respectively. Advanced T4 classification was associated with poorer response rate (p value=0.042). The major (grade 3-4) treatment-related toxicities were myelosuppression (78%), anorexia (13%), diarrhea (7%), emesis (11%) and stomatitis/pharyngitis (24%).
Conclusion: In comparison with the data of historical published trials of the PF regimen, the TPF regimen was more effective. However, the TPF regimen appears to be associated with a higher incidence of major toxicities.
Therefore, our limited findings support the TPF regimen as an alternative chemotherapeutic regimen for advanced head and neck carcinomas.
 
Keyword(s): DOCETAXEL, CISPLATIN, 5-FLUOROURACIL, CHEMOTHERAPY, HEAD AND NECK, CARCINOMA
 
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