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Journal:
IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES
SPRING 2010
, Volume 6
, Number 2; Page(s)
133
To
140. |
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Paper:
Antioxidant Activities And Phenolic Content Of Juniperus Excelsa Extract
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Author(s):
Moein Soheila, Moein Mahmoodreza*
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* DEPARTMENT OF PHARMACOGNOSY, AND PHARMACEUTICAL SCIENCES RESEARCH CENTER, FACULTY OF PHARMACY, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ 71345, IRAN |
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Abstract:
Butyl-hydroxytoluene (BHT) is one of the major synthetic antioxidants with a wide range usage. Replacement of artificial antioxidants with natural antioxidants is highly considered. In this research, the antioxidant activity of Juniperus excelsa was investigated by using reducing power, DPPH radical scavenging and inhibition of lipid peroxidation. Also, the amounts of phenolic and flavonoid compounds were determined. Ethanol extract of Juniperus excelsa was fractionated based on increasing the polarity. The reducing power of ethyl acetate fraction was more than butanol fraction. The IC50 of ethyl acetate fraction (204.3±12.8 mg/ml) was less than that of butanolic (>400 mg/ml) fraction (p<0.0001). The IC50 of standard antioxidants such as BHT and gallic acid were 63.17±0.9 mg/ml and 2.49±0.06 mg/ml, respectively.In inhibition of b -carotene oxidation, ethyl acetate fraction had a remarkable effect (antioxidant activity coefficient, ACC=960±20) which was more than the butanolic (ACC=550.7±15.3) fraction (p<0.01). The greastest amount of phenolic compounds (44.5±4.2 mg/g) and flavonoids (0.169±0.005 mg/g) were in ethyl acetate fraction.The results show that, the polar fractions of Juniperus excelsa, especially ethyl acetate, had more antioxidant activity.
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Keyword(s): ANTIOXIDANT ACTIVITIES, β-CAROTENE BLEACHING, DPPH SCAVENGING, JUNIPERUS EXCELSA, PHENOLICS, REDUCING POWER |
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Citations:
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APA: CopyMOEIN, S., & MOEIN, M. (2010). ANTIOXIDANT ACTIVITIES AND PHENOLIC CONTENT OF JUNIPERUS EXCELSA EXTRACT. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 6(2), 133-140. https://www.sid.ir/en/journal/ViewPaper.aspx?id=206187 Vancouver: CopyMOEIN SOHEILA, MOEIN MAHMOODREZA. ANTIOXIDANT ACTIVITIES AND PHENOLIC CONTENT OF JUNIPERUS EXCELSA EXTRACT. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2010 [cited 2022August15];6(2):133-140. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=206187 IEEE: CopyMOEIN, S., MOEIN, M., 2010. ANTIOXIDANT ACTIVITIES AND PHENOLIC CONTENT OF JUNIPERUS EXCELSA EXTRACT. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, [online] 6(2), pp.133-140. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=206187.
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