SID.ir New Version

Use Online Translation Powered By

Click Here STRS

STRS

Paper Information
Journal:   ARCHIVES OF IRANIAN MEDICINE   JANUARY 2011 , Volume 14 , Number 1; Page(s) 32 To 38.
 
Paper: 

Repeated Pretreatment Of Morphine Prevents Morphine-Induced Amnesia: A Possible Involvement For Dorsal Hippocampal Nmda Receptors
 
DOI: 

011141/AIM.008

 
Author(s):  Zarrindast Mohammad Reza*, Asadi Fereshteh, Rezayof Ameneh
 
* DEPARTMENT OF PHARMACOLOGY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 
Background: Learning and memory processes can be affected by morphine administration. It has been previously demonstrated that the effects of morphine depend on the timing of drug administration. In the present study, the effects of microinjections of a NMDA receptor agonist and antagonist into the CA1 regions of the dorsal hippocampi (intra-CA1) on repeated pretreatment of morphine-induced prevention of morphine-induced amnesia have been investigated.Methods: Step-through inhibitory avoidance task of memory has been used to examine retrieval of memory formation, 24 h after training in male Wistar rats.Results: The results indicate that post-training administration of morphine (7.5 mg/kg) impaired memory retrieval, but not in the animals, which received previous repeated morphine (7.5 and 10 mg/kg) injections followed by morphine withdrawal. Repeated co-administration of NMDA (7.5 and 10 ng/rat, intra-CA1) with an ineffective dose of morphine (5 mg/kg), once daily for three days reversed morphine-induced amnesia. Repeated bilateral intra-CA1 microinjections of NMDA, once daily for three days followed by a five-day washout had no effect on the expression of amnesia produced by post-training morphine. Three-day administration of the NMDA receptor antagonist, D-AP5 (0.5–2 mg/rat, intra-CA1) followed by a five-day washout had no effect on morphine-induced amnesia. On the other hand, intra-CA1 microinjections of the same doses of D-AP5 prior to injection of 7.5 mg/kg of morphine (per day×3 days) decreased the reversal of morphine-induced amnesia.Conclusion: These data imply that the dorsal hippocampal NMDA receptor mechanism(s) may modulate the effect-induced by repeated morphine administration on a challenge dose of morphine-induced amnesia.
 
Keyword(s): D-AP5, MEMORY, MORPHINE, NMDA, RAT(S)
 
 
International related papers: 
 
Most related Highly related Moderately related Least related
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

ZARRINDAST, M., & ASADI, F., & REZAYOF, A. (2011). REPEATED PRETREATMENT OF MORPHINE PREVENTS MORPHINE-INDUCED AMNESIA: A POSSIBLE INVOLVEMENT FOR DORSAL HIPPOCAMPAL NMDA RECEPTORS. ARCHIVES OF IRANIAN MEDICINE, 14(1), 32-38. https://www.sid.ir/en/journal/ViewPaper.aspx?id=205919



Vancouver: Copy

ZARRINDAST MOHAMMAD REZA, ASADI FERESHTEH, REZAYOF AMENEH. REPEATED PRETREATMENT OF MORPHINE PREVENTS MORPHINE-INDUCED AMNESIA: A POSSIBLE INVOLVEMENT FOR DORSAL HIPPOCAMPAL NMDA RECEPTORS. ARCHIVES OF IRANIAN MEDICINE. 2011 [cited 2022August07];14(1):32-38. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=205919



IEEE: Copy

ZARRINDAST, M., ASADI, F., REZAYOF, A., 2011. REPEATED PRETREATMENT OF MORPHINE PREVENTS MORPHINE-INDUCED AMNESIA: A POSSIBLE INVOLVEMENT FOR DORSAL HIPPOCAMPAL NMDA RECEPTORS. ARCHIVES OF IRANIAN MEDICINE, [online] 14(1), pp.32-38. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=205919.
 
  pdf-File
Yearly Visit 47
 
 
Latest on Blog
Enter SID Blog