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Journal:   ARCHIVES OF IRANIAN MEDICINE   JANUARY 2011 , Volume 14 , Number 1; Page(s) 12 To 17.
 
Paper: 

Autologous Transplantation Of Bone Marrow-Derived Mononuclear And Cd133+ Cells In Patients With Decompensated Cirrhosis

 
 
Author(s):  Nikeghbalian Saman, Pournasr Behshad, Aghdami Nasser, Rasekhi Alireza, Geramizadeh Bita, Hosseini Asl Seyed Mohammad Kazem, Ramzi Mani, Kakaei Farzad, Namiri Mehrnaz, Malekzadeh Reza, Vosough Dizaj Ahmad, Malek Hosseini Seyed Ali, Baharvand Hossein*
 
* DEPARTMENT OF STEM CELLS AND DEVELOPMENTAL BIOLOGY, DEPARTMENT OF REGENERATIVE MEDICINE, ROYAN INSTITUTE FOR STEM CELL BIOLOGY AND TECHNOLOGY, ACECR, TEHRAN, IRAN
 
Abstract: 
Background: Cirrhosis, the end stage of progressive hepatic fibrosis, is characterized by distortion of the hepatic architecture and the formation of regenerative nodules. Liver transplantation is one of the few available therapies for such patients. However, due to a severe shortage of organ donors, surgical complications, transplant rejection and the high cost of this procedure much interest has focused on research to nd new treatment modalities for this disease. There is accumulating evidence for the contribution of bone marrow stem cells to participate in liver regeneration.Methods: Here we report on six patients with end stage liver disease who were subjected to intraportal administration of autologous bone marrow-derived CD133+in comparison to mononuclear cells in short-term (6 months) and long-term (24 months) follow up.Results: There were no adverse effects in any of the patients during the short-and long-term follow up period. Moreover, there were no signicant alterations of liver function parameters, liver enzymes, serum albumin, creatinine, serum bilirubin and/or liver volume after transplantation of both types of autologous cells in these patients.Conclusion: Our study has shown both the safety and feasibility of this type of liver cell therapy and may be a bridge to liver transplantation.The trial was registered with NIH clinical trials (www.clinicaltrials.gov) as identier: NCT00713934.
 
Keyword(s): AUTOLOGOUS TRANSPLANTATION, BONE MARROW, DECOMPENSATED CIRRHOSIS, LIVER
 
 
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APA: Copy

NIKEGHBALIAN, S., & POURNASR, B., & AGHDAMI, N., & RASEKHI, A., & GERAMIZADEH, B., & HOSSEINI ASL, S., & RAMZI, M., & KAKAEI, F., & NAMIRI, M., & MALEKZADEH, R., & VOSOUGH DIZAJ, A., & MALEK HOSSEINI, S., & BAHARVAND, H. (2011). AUTOLOGOUS TRANSPLANTATION OF BONE MARROW-DERIVED MONONUCLEAR AND CD133+ CELLS IN PATIENTS WITH DECOMPENSATED CIRRHOSIS. ARCHIVES OF IRANIAN MEDICINE, 14(1), 12-17. https://www.sid.ir/en/journal/ViewPaper.aspx?id=205908



Vancouver: Copy

NIKEGHBALIAN SAMAN, POURNASR BEHSHAD, AGHDAMI NASSER, RASEKHI ALIREZA, GERAMIZADEH BITA, HOSSEINI ASL SEYED MOHAMMAD KAZEM, RAMZI MANI, KAKAEI FARZAD, NAMIRI MEHRNAZ, MALEKZADEH REZA, VOSOUGH DIZAJ AHMAD, MALEK HOSSEINI SEYED ALI, BAHARVAND HOSSEIN. AUTOLOGOUS TRANSPLANTATION OF BONE MARROW-DERIVED MONONUCLEAR AND CD133+ CELLS IN PATIENTS WITH DECOMPENSATED CIRRHOSIS. ARCHIVES OF IRANIAN MEDICINE. 2011 [cited 2022June29];14(1):12-17. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=205908



IEEE: Copy

NIKEGHBALIAN, S., POURNASR, B., AGHDAMI, N., RASEKHI, A., GERAMIZADEH, B., HOSSEINI ASL, S., RAMZI, M., KAKAEI, F., NAMIRI, M., MALEKZADEH, R., VOSOUGH DIZAJ, A., MALEK HOSSEINI, S., BAHARVAND, H., 2011. AUTOLOGOUS TRANSPLANTATION OF BONE MARROW-DERIVED MONONUCLEAR AND CD133+ CELLS IN PATIENTS WITH DECOMPENSATED CIRRHOSIS. ARCHIVES OF IRANIAN MEDICINE, [online] 14(1), pp.12-17. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=205908.



 
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