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Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   WINTER 2011 , Volume 9 , Number SUPPL 1; Page(s) 70 To 71.
 
Paper: 

THE DISTRIBUTION OF UTERUS NATURAL KILLER CELLS ON PREGNANANT MICE AFTER HYPER STIMULATION PROTOCOL

 
 
Author(s):  DOORFESHAN P., SALEHNIA M.*, MOEZENI M.
 
* DEPARTMENT OF ANATOMY, TARBIAT MODARES UNIVERSITY, TEHRAN, IRAN
 
Abstract: 
Introduction: Natural Killer cellsare predominant immune cells in decidua early pregnancy and these cells express progesteron receptors.
Hyperstimulation process results in supraphysiological concentrations ofesterogen and progesteron. In this study, the distribution of classic NK cells in hyperstimylated mice in comparisson with control group were studied.
Materials and Methods: For this purpose, the sampaleswere obtained from implantation sites of NMARI pregnant mice at seventh day of pregnancy after hyperstimulation with PMSG and HCG. Cryosections at 5 micrometerethickness were provided from endometrium of both groups and stained with CD3 and CD161 monoclonal antibodies by double staining immunohistochemical method. NKcells were studied under light microscope at 400x magnification.
Results: The results showed that the distribution of CD3−CD161+NK cells almost similar in decidua ofhyperstimulated and control groups. These cells mainly observed in decidua and myometrum.It seems that NK cells population was prominent in hyperstimylated group in compare to the control group.
Conclusion: This increase may be related to the expression of progesterone receptore by Natural Killer cells and it may affect on the implantation process.However it needs additional studies.
 
Keyword(s): NATURAL KILLER CELLS, HYPER STIMULATION, PREGNANCY
 
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