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Paper Information

Journal:   KOWSAR MEDICAL JOURNAL   SPRING 2011 , Volume 16 , Number 1; Page(s) 39 To 44.
 
Paper: 

SURVIVAL RATE OF PATIENTS SUFFERING FROM GASTRIC ADENOCARCINOMA OF YAZD CITY

 
 
Author(s):  AKHAVAN A.*, BASHARDOUST N.A., MOGHIMI M., SEIFADINI A., SALEHI MOHAMMAD
 
* SHAHID RAMEZANZADEH RIDIOTHERAPY CENTER, SHAHID SADUGHI UNIVERSITY OF MEDICAL SCIENCES, YAZD, IRAN
 
Abstract: 

Aims: Gastric cancer is one of the most common cancers in Iran and is one of the most frequent causes of death due to cancer. Despite progresses in treatment, it still causes much mortalities and its treatment is still a matter of debate in the world. This study was performed with the aim of investigating the factors affecting prognosis, the survival rate and effect of different treatments on survival in gastric adenocarcinoma patients.
Materials & Methods: This analytical case series study was conducted on 47 gastric or cardia adenocarcinoma patient referring to Shahid-Ramezanzadeh Radiation Center from 2004 to 2009 and were selected by accessible sampling. Data was extracted from patients' records and follow up was conducted through telephone contacts.
Kaplan-Meier curves and SPSS 13 software were used for data analysis.
Results: Two-year and three-year survival of patients were 50% and 30%, respectively. Mean survival rate was 29.9 months and mean disease free survival rate was 12.95 months. Survival rate revealed a significant relation with disease stage (p=0.046), performed therapies (p=0.027) and surgical margin. Patients who had received a combination of surgery, chemotherapy and radiation therapy had the best survival. Survival had no relation with type of adenocarcinoma, tumor location or grade and chemotherapy regimen.
Conclusion: Age, gender, surgery type, tumor location or grade and chemotherapy regimen do not affect survival, but the disease stage, performed therapies and surgical margin affect it. It seems that a combination of surgery, chemotherapy and radiation therapy would provide the best effect on patents' survival.

 
Keyword(s): SURVIVAL, GASTRIC CANCER, ADENOCARCINOMA, NEOADJUVANT, CHEMO-RADIATION
 
References: 
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