| Abstract:
Due to attention of the increasing usage of drugs against Fasciola sp. in Iran and irregular consumption of some of pharmaceutical anti-helminth compounds, present study carried out in order to evaluate the effectiveness of triclabendazole and albendazole (made in Iran) against infection with Fasciola sp. and the existence of drug resistant in sheep.
Fecal samples from 22 herds with natural infections were collected directly from the rectum of sheep in different regions of Gilan province. The samples were subjected to coproscopical examination using floatation method and then were determined egg per gram (EPG) of feces. Six herds were totally selected for test. Four herds administrated with 10 mg/kg and 2 herds 7.5 mg/kg body weight of triclabendazole and albendazole, respectively. Five sheeps from the each herd were feed with placebo as control.
Fecal examination of samples were done separately in days of 8, 18 and 28 post treatments. In order to exact evaluation of drugs, necropsy were done in six sheeps one month after treatment. The EPG counts in the triclabendazole group were 0 in 8 days after treatment and this process continued until the end of treatment period. The mean of Fasciola sp. eggs count in albendazole group were 5, 5.8 and 9.5 in 8, 18 and 28 post treatment, respectively. The results of necropsy in 6 sheeps from triclabendazole group confirmed the results of stool examination concerning 100% effectiveness of this drug on Fasciola. sp. But the results of necropsy in 6 sheeps of albendazole group showed infection with Fasciola sp. in 4 sheep. Based on this study, triclabendazole is an absolutely effective drug against Fasciola, sp. while albendazole was less effective against this parasite and some gastrointestinal nematodes. This may be due to drug resistance or effective dose of drug which further studies proposed.
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