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Paper Information

Journal:   INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH (IJER)   SUMMER 2010 , Volume 4 , Number 3; Page(s) 439 To 442.
 
Paper: 

THE BIOLOGICAL MONITORING OF URINARY 1-HYDROXYPYRENE BY PAH EXPOSURE AMONG SMOKERS

 
 
Author(s):  LEE K.H., BYEON S.H.*
 
* DEPARTMENT OF ENVIRONMENTAL HEALTH, COLLEGE OF HEALTH SCIENCE, KOREA UNIVERSITY, S. KOREA
 
Abstract: 

This study examines changes in the urinary 1-hydroxypyrene (1-OHP) concentration as a polycyclic aromatic hydrocarbon (PAH) metabolite related to smoking among eight volunteers. The study subjects consisted of 8 participants (2 smokers, 4 ex-smokers and 2 non-smokers; mean age 23, range 21 ~ 24 years old) in a smoking cessation program. Three urine samples were collected each week for 4 weeks from each participant to give a total of 96 urine samples. None of the participants smoked during the study period. Levels of urinary 1-OHP, as an internal dose marker of smoke containing PAHs, were measured by high performance liquid chromatography (HPLC) fluorescence detector. Urinary 1-OHP levels in the ex-smokers were decreased during the 4 weeks study period, due to ambient sources of PAH exposure. Thus, smoking cessation was only expected to result in reduction of urinary 1-OHP. Urinary 1-OHP levels were significantly correlated with the amounts of cigarettes smoked, as assessed by the questionnaire (Spearman’s correlation coefficient, r=0.23, P=0.03). This study suggested that urinary 1-OHP can be a potentially useful biomarker of smoke.

 
Keyword(s): BIOMARKER, POLYCYCLIC AROMATIC HYDROCARBONS, 1-HYDROXYPYRENE, CIGARETTE SMOKING
 
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