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Paper Information

Journal:   RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)   OCTOBER 2008 , Volume 3 , Number 2; Page(s) 87 To 93.
 
Paper: 

SYNTHESIS AND THE COMBINATION EFFECTS OF DIHYDROPYRIDINE ANALOGS WITH SELECTED ANTIBIOTICS AGAINST RESISTANT STAPHYLOCOCCUS AUREUS

 
 
Author(s):  AKBARZADEH T., MOTAGIAN S., FALLAH TAFTI A., SHAFIEI A., SHAHVERDI A.R.*
 
* DEPARTMENT OF PHARMACEUTICAL BIOTECHNOLOGY AND BIOTECHNOLOGY RESEARCH CENTER, FACULTY OF PHARMACY, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, I.R.IRAN
 
Abstract: 

Bacterial resistance is a major drawback in chemotherapy of infectious diseases. In this investigation a new series of 3,5-diarylamide dihydropyridines containing 2-benzylsulfonylimidazol at 4 position have been synthesized and studied for their enhancing effect on the antibacterial activities of different penicillins against a resistant clinical isolate of Staphylococcus aureus using disc diffusion method. During preliminary screening, compound 6d showed the most enhancing effect on the antibacterial activity of amoxicillin against the test strain and the combination effect of this compound has been further studied with penicillin G and piperacillin against S. aureus. The result of this evaluation showed that the antibacterial activities of penicillin G and piperacillin can be also enhanced by compound 6d suggesting a possible utilization of this compound in combination therapy against penicillin resistant S. aureus.

 
Keyword(s): SYNTHESIS, 3,5-DIARYLAMIDE DIHYDROPYRIDINES, COMBINATION EFFECT, ANTIBACTERIAL ACTIVITY, STAPHYLOCOCCUS AUREUS
 
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