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Paper Information

Journal:   IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)   DECEMBER 2009 , Volume 3 , Number SUPPLEMENT 1 (12TH INTERNATIONAL CONGRESS OF NEPHROLOGY, DIALYSIS, AND TRANSPLANTATION); Page(s) 91 To 91.
 
Paper: 

EFFECT OF OMEGA-3 SUPPLEMENTATION ON PLASMA LEVEL OF HOMOCYSTEINE IN HEMODIALYSIS PATIENTS (POSTER PRESENTATIONS: P351)

 
 
Author(s):  TAYEBI KHOSROUSHAHI H., HABIBIASL B., DEHGHAN R., SAFAIAN A., HOUSHYAR J., NOURAZARIAN A., VATANKHAH A.M.
 
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Abstract: 

Introduction. Elevated total homocysteine (tHcy) levels are common among end-stage renal disease (ESRD) patients on chronic dialysis with increasing the risk of cardiovascular disease. There is some controversial study about the effect off Omega-3 (fish oil) on plasma homocysteine level in dialysis patients. The aim of the present study was to further evaluate the effect of Omega-3 supplementation on plasma homocysteine levels in homodialysis patients.
Methods. In a clinical trial, 100 voluntary patients on chronic hemodialysis were selected and divided into 2 groups randomly. Group 1: Omega 3 group: these patients received omega 3, as a capsule three gram/d for two months; group 2: these patients were on placebo. CBC, routine laboratory test, and total homocysteine level were measured before and after two months in both groups. Statistical analysis was performed using SPSS 16 and ANOVA test. A P value was set to be significant at 0.05.
Results. Only 44 patients from each group completed the study. There was no statistically significant difference between the 2 groups regarding the age, gender, and duration on dialysis. Routine laboratory tests were also not significantly different at the end of the study between the 2 groups. There was significant reduction of serum homocysteine level in omega 3 treated group after two months (P = 0.03). Hb level was also not significantly elevated in omega 3 group (P > 0.05).
Conclusion. In conclusion, it seems that Omega 3 fatty acid is a safe and effective nutrient that may have a beneficial effect in reduction of morbidity and also mortality of the dialysis patients with reduction of homocysteine level.

 
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