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Paper Information

Journal:   IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)   DECEMBER 2009 , Volume 3 , Number SUPPLEMENT 1 (12TH INTERNATIONAL CONGRESS OF NEPHROLOGY, DIALYSIS, AND TRANSPLANTATION); Page(s) 72 To 73.
 
Paper: 

EFFICACY OF ORAL GRANISETRON IN UREMIC PRURITUS (POSTER PRESENTATIONS: P308)

 
 
Author(s):  MOJAHEDI M.J., LAYEGH P., TABAR MALEKSHAH E., SHARIFPOUR F., VAHEDIAN MOHAMMAD, NAZEMIAN F.
 
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Abstract: 

Introduction. Uremic pruritus is a relatively common and distressing problem for patients with chronic renal failure. Serotonin and histamine have been reported as possible mediators of uremic pruritus. Granisetron, a potent and selective inhibitor of 5-HT3 receptors was developed for relief of chemotherapy-induced nausea. There are some studies about effect of ondansetron in uremic pruritus and recently, one case report described relief of renal itching by Granisetron. The aim of our study was to evaluate the effect of Granisetron on uremic pruritus in patients with chronic renal failure on dialysis.
Methods. Fourteen uremic patients on hemodialysis with moderate and severe pruritus were enrolled in this open trial. Patients received Granisetron tablet (1 mg twice a day) for 1 month and were asked to complete a questionnaire assessing the severity of pruritus, twice a day.
Results. A total of 77% of the patients responded to the treatment and on the 1st, 2nd, and 4th weeks of treatment, the mean values of pruritus score were 23 (range, 11 to 40), 16 (range, 8to 35), and 8 (range, 0 to 35) points, respectively, while at baseline (before treatment) it was 31 (range, 20 to 35) points (P = 0.03). Pruritus disappeared in 7 patients at the end of the 4th week, and was mild in 3 others. This effect was maintained during the study. Weekly clinical and laboratory examinations showed no side effects.
Conclusion. Granisetron may be an effective, safe, and well tolerated drug for the treatment of uremic pruritus in hemodialysis patients.

 
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