Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)   DECEMBER 2009 , Volume 3 , Number SUPPLEMENT 1 (12TH INTERNATIONAL CONGRESS OF NEPHROLOGY, DIALYSIS, AND TRANSPLANTATION); Page(s) 49 To 50.
 
Paper: 

ORAL CALCITRIOL AND GLUCOSE INTOLERANCE AND DYSLIPIDEMIA IN HEMODIALYSIS PATIENTS (POSTER PRESENTATIONS: P229)

 
 
Author(s):  MOJAHEDI M.J., BONAKDARAN S., HAMI M., SHEYKHAN M.
 
* 
 
Abstract: 

Introduction. This study was conducted to assess the effect of oral calcitriol on glucose metabolism in patients on hemodialysis (HD).
Methods. A total of 27 patients on HD at Mashhad University of Medical Sciences, none of whom had received calcitriol or had history of diabetes, were selected. The patients were randomly divided into two groups; group I; patients who received oral calcitriol for eight weeks and, group II; patients who received placebo. In all cases, levels of fasting glucose, insulin, lipid profile, calcium, phosphorous, parathormone (PTH), HbA1C and blood sugar after administration of 75 grams of glucose, insulin resistance, and beta cell function were measured, before and after the treatment period. The two sets of results were then compared with one another.
Results. In group l, the levels of the parameters studied before and after the study period were as follow: blood sugar after 75 grams of glucose (88.67
± 8.68 versus 99.83 ± 34.42 mg/dl, P = 0.045), HOMA-IR (2.05 ± 1.42 versus 2.42 ±1.33, P = 0.035), HbA1C (5.99 ± 1.00 versus 6.14 ± 1.19, P < 0.001), total cholesterol (153.3 ±43.80 mg/dl versus 157.0 ± 52.62, P = 0.037) and triglycerides (175.30 ± 99.65 versus 214.9 ± 117.7 mg/dl, P = 0.036). In Group II, fasting blood sugar (110.7 ± 26.12 versus 81.14 ± 13.31 mg/dl, P = 0.002), HbA1C (6.99 ± 1.44 versus 6.17 ± 1.66, P = 0.004) and HOMA-IR (5.85 ± 5.11 versus 3.20 ± 2.39, P = 0.036) significantly increased and beta cell function significantly decreased (149.5±90.57 versus 355.7 ± 299.3, P = 0.032) after the study period.
Conclusion. In conclusion, our results show that vitamin D has a significant influence on glucose metabolism. Similar studies on larger sample sizes are required to confirm this observation.

 
Keyword(s): 
 
References: 
  • ندارد
 
  Yearly Visit 46
 
Latest on Blog
Enter SID Blog