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Paper Information

Journal:   IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)   DECEMBER 2009 , Volume 3 , Number SUPPLEMENT 1 (12TH INTERNATIONAL CONGRESS OF NEPHROLOGY, DIALYSIS, AND TRANSPLANTATION); Page(s) 43 To 44.
 
Paper: 

COMPARING THE EFFECT OF CLONAZEPAM AND ZOLPIDEM ON SLEEP QUALITY OF PATIENTS ON MAINTENANCE HEMODIALYSIS (POSTER PRESENTATIONS: P212)

 
 
Author(s):  DASHTI KHAVIDAKI S., CHAMANI N., AHMADI F., KHALILI H., LESANPEZESHKI M., ASHOURI A.
 
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Abstract: 

Introduction. Sleep disorders are very common problems in maintenance hemodialysis patients (MHP). Poor sleep quality has negative impact on patients’ quality of life. Benzodiazepines have been used widely in HD patients who suffer sleep disorders; however, their potential to induce physical dependence remains a matter of concern. Non-benzodiazepine drugs such as zaleplon and zolpidem have been used as hypnotic agents without inducing physical dependence. Zaleplon has been administered in some European HD patients with insomnia and has shown positive effect on the sleep quality according to Pittsburgh questionnaire. Zolpidem, another non-benzodiazepine hypnotic medication is available in generic form in Iran. This study was designed to compare the effect of zolpidem on sleep quality of MHD patients with routinely administered benzodiazepine, clonazepam, In Iran.
Methods. During a double-blind, cross-over clinical trial on 16 MHD patients in Imam-Khomeini hospital between February 2009 and May 2009, sleep quality was assessed according to validated Iranian version of Pittsburgh questionnaire at baseline, after 2-weeks washout period of any previously administered sedative/hypnotic agents, after 2-weeks of zolpidem, and clonazepam with 3-4 nights wash out period between crossing process.
Results. The findings of this study showed that both drugs significantly improved sleep quality in MHD patients and after excluding period effect, clonazepam significantly improved sleep quality more than zolpidem.
Conclusion. According to the results of this study, clonazepam improves sleep quality more than zolpidem in MHD patients.

 
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