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Paper Information

Journal:   IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)   DECEMBER 2009 , Volume 3 , Number SUPPLEMENT 1 (12TH INTERNATIONAL CONGRESS OF NEPHROLOGY, DIALYSIS, AND TRANSPLANTATION); Page(s) 19 To 19.
 
Paper: 

ORAL VITAMIN E AND RENAL ANEMIA IN CHRONIC HEMODIALYSIS CHILDREN (POSTER PRESENTATIONS: P126)

 
 
Author(s):  ESMAEILI M., GHANE F.
 
* 
 
Abstract: 

Introduction. Renal anemia is one of the most frequently observed complications in patients undergoing chronic hemodialysis (HD). Reduced red blood cell survival due to oxidative damage is one of the causes of anemia in these patients. Vitamin E (alpha – tocopherol) is a natural biological antioxidant, which protects red cells from the effects of reactive oxygen metabolites and could be useful as a collateral therapy for anemia in HD patients. The aim of the present study was to investigate the potential beneficial effect of anti-oxidant vitamin E supplementation (oral) on renal anemia and to find out whether this improvement mechanism is attributable to the enhanced hematopoietic function or to the prolonged RBC life.
Methods. This clinical trial study included (8 cases with mean age of 14
± 2.9 years and 7 controls with mean age of 14 ± 2.7 years) stable children on chronic hemodialysis, at hemodialysis center in Sheikh children hospital, Mashhad. At the time of entry, there was no evidence of iron deficiency or history of blood transfusion. All of the children (case and control) received subcutaneous erythropoietin (EPO) with the dose of 120 ± 80 u/kg/ BW/week, folic acid with the dose of 1 mg/day, and iron with the dose of 1 to 2 mg/kg/day. Oral vitamin E (200 u/day) for 3 months was only prescribed to the cases. Laboratory parameters determined at the beginning of the study were: iron, ferritin, transferrin, total iron binding capacity, hemoglobin (Hb), hematocrit, reticulocyte count, and peripheral blood smear. Hb and HCT were checked every month during the study and the results were compared with those obtained earlier.
Results. Prescription of oral vitamin E for 3 months resulted in significantly higher levels of Hb and HCT in the cases compared to those in the controls (11.4
± 1.7 vs. 10.1 ± 1.9 Hb and 35.3 ±5 vs. 31.3 ± 6 Htc, P < 0.05).
Conclusion. Antioxidant vitamin E supplementation improves renal anemia by decrease of oxidative stress and RBC life span in hemodialysis patients.

 
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