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Paper Information

Journal:   IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY   SUMMER 2008 , Volume 2 , Number 2; Page(s) 27 To 33.
 
Paper: 

THE DIVERSITY OF AMINOGLYCOSIDE RESISTANCE PATTERN AMONG SALMONELLA SPP. ISOLATED FROM CLINICAL CASES IN TEHRAN

 
 
Author(s):  RANJBAR REZA*, NAGHOUNI A., TABARAEI BAHMAN
 
* MOLECULAR BIOLOGY RESEARCH CENTER, BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background and objectives: Salmonella is recognized as a major food-borne pathogen in humans worldwide. Antimicrobial drug resistance is increasing among Salmonella spp. and causes significant therapeutic problems –in the treatment of diseases caused by this organism. The aim of this study was to determine the aminoglycoside resistance pattern of Salmonella spp. isolated from clinical cases in Tehran.
Material and Methods: Salmonella spp. strains were isolated from several hospitals in Tehran during 2007-2008. The strains were identified by standard biochemical methods and serology. The susceptibility of the isolates to aminoglycoside antibiotics was determined according to Clinical and Laboratory Standards Institute (CLSI) guidelines.
Results: The results showed that 44.1% of the strains were resistant to streptomycin, 22.8% to kanamycin, 19.1% to neomycin, 0.7% to tobramycin and 0% to gentamycin.
Conclusion: We found a diverse pattern of aminoglycosides resistance among Salmonella spp., the resistance to streptomycin and kanamycin was considerable, whereas to tobramycin and gentamycin was very low. While aminoglycoside resistance varied by Salmonella serogroups, continuous monitoring of resistance patterns and the use of antibiotic agents according to individual serogroup is recommended.

 
Keyword(s): SALMONELLA SPP., AMINOGLYCOSIDE RESISTANCE, ANTIBIOTIC SUSCEPTIBILITY TESTING
 
References: 
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  Persian Abstract Yearly Visit 58
 
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