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Paper Information

Journal:   JOURNAL OF DENTAL SCHOOL SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCE   FALL 2009 , Volume 27 , Number 3 (81); Page(s) 146 To 154.
 
Paper: 

EFFECT OF LOCAL HYPOTHERMIA IN PREVENTION OR REDUCTION OF CHEMOTHERAPY INDUCED MUCOSITIS SIGNS

 
 
Author(s):  TAHERI J.B.*, RAZAVI SEYED MOHSEN, HAZHIR S., VAZIRI PEZHMAN, BAKHTIARI SEDIGHEH
 
* DEPT. OF ORAL MEDICINE, DENTAL SCHOOL AND DENTAL RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background and Aim: Oral mucositis frequently occurs in patients undergoing cancer chemotherapy. It is hypothesized that Oral Cooling with ice chips or cubes cause local vasoconstriction thus cause less exposure to agents & then mucositis development. In this study, this theory was examined on 14 patients in 3 consecutive cycles in which stomatitis developed in the 1st cycle of treatment. The purpose of the present study was to evaluate the Ice-Therapy (mouth-cooling) in prevention or decreasing symptoms of chemotherapeutic-related stomatitis.

Patients & Methods: Date was obtained on a total of 100 out-patients initiating chemotherapy regimens. The patients reported different rates of stomatitis received ice cubes in their 2nd cycle of treatment during the drug infusion & a few minutes after it. In the next cycle, the same patients were evaluated without mouth cooling. The severity of mucositis were measured based on the patient's judgment & scaled on WHO grading system in the 7th & 10th days. Statistically, comparison of severity rates of mucositis between 3 consecutive cycles were performed by mean, p value, GAMMA coefficient & Friedman test.

Results: Statistical approach of data between 3 cycles determined that severity rates of mucositis have been decreased significantly between 1st& 2nd cycles (p<0.01, gamma coefficient: 65%) But this relationship has not been obtained in comparison between 2nd & 3rd cycles so it has been speculated that Oral Cooling has no useful effect on the prevention of chemotherapy-induced mucositis.

Conclusion: Oral Cooling has no evidence of benefit in improvement or decreasing of the chemotherapy induced lesions.

 
Keyword(s): HYPOTHERMIA, MUCOSITIS, CHEMOTHERAPY
 
References: 
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