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Paper Information

Journal:   IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY   FALL 2008-WINTER 2009 , Volume 2 , Number 3-4; Page(s) 59 To 65.
 
Paper: 

ANTIBIOTIC RESISTANCE PATTERNS OF ENTEROPATHOGENIC E.COLI (EPEC) SEROGROUPS ISOLATED FROM STOOL OF UNDER 5 YEARS OLD CHILDREN WITH DIARRHEA IN TEHRAN: 2007- 2008

 
 
Author(s):  SHIRAZI M.H., AKBARI A.A.F., SHARIFI YAZDI MOHAMMAD KAZEM, HOSSEINI MOSTAFA, FARDSANEI F., BAKHTIARI ROUNAK, SOLTAN DALAL MOHAMMAD MAHDI*
 
* DIVISION OF MICROBIOLOGY, DEPARTMENT OF PATHOBIOLOGY, SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH, TEHRAN UNIVERSITY OF MEDICAL SCIENCES (TUMS), TEHRAN, IRAN
 
Abstract: 

Background and objectives: Enteropathogenic E.coli (EPEC) strains have high prevalence in children and are of the most important diarrheagenic agents in developed and developing countries that may cause severe diarrhea even death. Prevalence and antibiotic resistance patterns differ in different geographic areas.
Knowledge of the patterns is necessary for physicians in order to treatment of infections using appropriate antibiotics. This research aimed to detection of common EPEC serogroups in diarrheal under 5 year old children and study the patterns of antibiotic resistance of these strains.
Materials and Methods: 278 samples collected from children with diarrhea visited in Ali Asghar hospital, Tehran. Bacterial isolates confirmed as EPEC serogroups on the basis of standard biochemical and serological tests. Antibiotic susceptibility testing was performed using 16 different antibiotic discs by disc diffusion agar (Kirby-Bauer) method.
Results: In this study 19 cases (6.8%) of EPEC isolated that prevalence of EPEC strains particularly serogroup poly IV was more common in children under one year old. All strains were sensitive to meropenem and imipenem, 63.2 % were resistant to nalidixic acid, tetracycline and amoxicillin and 89.5 % of strains were sensitive to ceftazidime and gentamycin. Results indicated that most strains completely or intermediately were resistant to nalidixic acid, tetracycline and amoxicillin.
Conclusion: Antibiotic resistance of EPEC strains to nalidixic acid, tetracyclin and amoxiciline is increasing. Due to increasing resistance towards antibiotics, we should use new and effective antibiotics according to antibiotic susceptibility testing for treatment of infections.
 

 
Keyword(s): ENTEROPATHOGENIC ESCHERICHIA COLI, ANTIBIOTIC RESISTANCE, DIARRHEA, CHILDREN
 
References: 
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