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Paper Information

Journal:   ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)   WINTER 2010 , Volume 12 , Number 4 (49); Page(s) 51 To 60.
 
Paper: 

THE ROLE OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) IN ISCHEMIA/REPERFUSION-INDUCED ACUTE RENAL FAILURE IN ANAESTHETIZED RATS

 
 
Author(s):  GHOLAMPOUR F.*, SHID MOUSAVI SEYED MOSTAFA, OUJI S.M., HAJIZADEH S.
 
* BIOLOGY DEPARTMENT, FACULTY OF SCIENCES, ADABIAT JUNCTION, SHIRAZ UNIVERSITY, SHIRAZ, IRAN
 
Abstract: 

Background: Ischemia/reperfusion-induced acute renal failure causes excretory functional disorders of nephrones. Ischemia/reperfusion injury increases INOS expression in the renal tissue. Inhibition of INOS expression and its activity can ameliorate ischemia/reperfusion-induced renal injury. The aim of this study was to determine the role of INOS on progression of renal functional disturbances over the immediate post-ischemic reperfusion period.
Materials and Methods: In this experimental study, renal hemodynamic and excretory functions were evaluated in male Sprague-Dawley rats. First, a 30-min control clearance period was taken. Then following bilateral renal artery clamping for 30 minutes, four consecutive 30-min clearance periods were taken during reperfusion, while saline or L-NIL as a selective INOS inhibitor was infused. In plasma and urine samples, Cr and sodium concentration levels were measured.
Results: Renal ischemia for 30 minutes decreased glomerular filtration rate and urine osmolality during reperfusion and increased urine flow and sodium excretion. L-NIL did not change the glomerular filtration rate and urine osmolality prior to ischemia but it improved them during reperfusion and there were progressive increases in urine flow. Additionally, L-NIL lowered ischemia-induced rises in sodium excretion.
Conclusion: INOS had a considerable role in the development of disorders in hemodynamic and excretory renal functions during early hours after ischemia.

 
Keyword(s): GLOMERULAR FILTERATION, INOS ENZYME, ISCHEMIA, L-NIL, REPERFUSION
 
References: 
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