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Paper Information

Journal:   DARU JOURNAL OF PHARMACEUTICAL SCIENCE   SUMMER 2009 , Volume 17 , Number 3; Page(s) 168 To 174.
 
Paper: 

ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF PERGULARIA DAEMIA AND CARISSA CARANDAS

 
 
Author(s):  BHASKAR V.H.*, BALAKRISHNAN N.
 
* PATEL COLLEGE OF PHARMACY, KAPADWANJ, GUJARAT-387620, INDIA
 
Abstract: 

Background: The plant Pergularia daemia (Asclepiadaceae) and Carissa carandas (Apocynaceae) are traditionally used as a medicinal agent and they are widely distributed to tropical and subtropical region of India. In the present study the folklore uses of P. daemia and C. carandas was investigated.
Methods: The analgesic activity was studied in mice using hot plate and acetic acid induced writhing methods, while carrageenan induced paw edema was used to access anti-inflammatory activity. The antipyretic activity was evaluated by Brewer’s yeast induced pyrexia in rats.
Results: The ethanol and aqueous extracts from roots of P. daemia and C. carandas exhibited significant (p<0.01) analgesic, anti-inflammatory and antipyretic activities at the doses of 100 and 200 mg/kg body weight. In analgesic activity, the highest reaction time was observed (9.8 sec.) from ethanol extracts of P.daemia at a dose of 200 mg/kg body weight, while highest percentage of inhibition of abdominal constriction (72.67%) was observed for ethanol extracts of C.carandas at a dose of 100 mg/kg body weight. The ethanol and aqueous extracts of P. daemia and C. carandas were found to reduce significantly the formation of edema induced by carrageenan after 2 hrs. Both plants showed significantly competent on yeast induced hyperpyrexia in rats after 2 hrs.
Conclusion: The results of this study indicated that the ethanol and aqueous extracts from roots of P. daemia and C. carandas possess significant analgesic, anti-inflammatory and antipyretic activities in rodent models.

 
Keyword(s): ANALGESIC, ANTI-INFLAMMATORY, ANTIPYRETIC, CARISSA CARANDAS, PERGULARIA DAEMIA DARU
 
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