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Paper Information

Journal:   INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   MARCH 2009 , Volume 7 , Number 1; Page(s) 41 To 45.
 
Paper: 

MARFAN SYNDROME AND EARLY-ONSET DIABETIC RETINOPATHY: A CASE REPORT

 
 
Author(s):  PARK KA Y., AYDIN CRISTINA M., MAZANDARANI ADEL B., JOHNSON M., CHUI L., TILDESLEY HUGH D.*
 
* ROOM 416, 1033 DAVIE STREET, VANCOUVER, BRITISH COLUMBIA, V6E 1M7
 
Abstract: 

Diabetic retinopathy is characterized by the proliferation of fibro vascular tissue extending from the retina into the vi-treous cavity. MFS is an autosomal do-minant disorder of the elastic tissue. Al-though MFS clearly manifests with multiple ocular problems, there is no reported association between MFS and diabetic retinopathy. Reported here is the case of 32-year-old male with Marfan Syndrome (MFS) and type 2 diabetes mellitus (DM) presented with an accelerated onset of diabetic retinopathy. Our patient developed diabetic retinopathy only 4 years following the diagnosis of type 2 DM, de-spite excellent glucose control. We suggest that there may be a pathophysiological link between MFS and diabetes involving extracellular matrix components that accelerates and/or augments the retinopathic processes in MFS patients. Specifically, we postulate that increased levels of matrix metalloproteinase’s (MMP) and transforming growth factor beta (TGF b) in diabetic retinas facilitate the proteolysis of an already weakened ocular connective tissue in MFS, ultimately lead-ing to early development of ophthalmologic ma-infestations such as diabetic retinopathy.

 
Keyword(s): MARFAN SYNDROME, DIABETIC RETINOPATHY, TYPE 2 DIABETES, MATRIX METALLOPROTEINASES
 
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