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Paper Information

Journal:   JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES   SPRING 2009 , Volume 18 , Number 69; Page(s) 17 To 24.
 
Paper: 

THE HEPATO TOXIC EFFECTS OF LEAD ACETATE ON HEPATIC TISSUES IN NEW ZEALAND IAN RABBIT

 
 
Author(s):  ZAHEDI AFSHIN, KHAKI ARASH*, BAZI P., KHAKI AMIR AFSHIN
 
* DEPARTMENT OF PATHOLOGY, FACULTY OF VETERINARY, ISLAMIC AZAD UNIVERSITY OF TABRIZ, IRAN
 
Abstract: 

Introduction: Lead is one of the world wide using metals which have been used since ancient time. It is also a toxin, it has adverse effects on the body even at low level of exposure and it induces a broad range of physiological, biochemical, and behavioral dysfunctions. Studies have been showed that this metal has harmful effects on several tissues such as: nervous system, blood tissues, and cardiovascular system, reproductive and urinary system.
Objective: Survey the effect of Lead acetate on hepatic tissues in light and Electron microscope.
Materials and Methods: White male rabbits of New Zealand race were used and divided into two groups. Experimental groups (N=10) 6.5 mg/Kg of lead acetate were injected intra peritoneal and control group (N=10) were injected only with demonized water every day to each animal for 7 weeks .After taking biopsy from hepatic tissues of each group, tissue preparation was performed for LM and EM studies as standard method. Quantitave and qualitative (morphometeric and morphologic) studies were carried out on electro micrographs. Data was compared using statistically methods.
Results: Morphological and morphometerical findings showed the vacuolated of mitochondria of hepatocyte, degeneration of rough endoplasmic reticulum, heterochromatin of nuclei and reduce in lobular diameter in experimental group as compare with control group (P
£0.05).
Conclusion: Qualitative and quantitative study of chronic phase showed that lead Acetate caused obvious changes in hepatic tissues. 

 
Keyword(s): CYTOTOXINS, LEAD, LIVER, RABBITS
 
References: 
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