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Paper Information

Journal:   IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE   JANUARY 2007 , Volume 11 , Number 35; Page(s) 33 To 39.
 
Paper: 

HEPATITIS C VIRUS INFECTION AMONG HAEMOPHILIA AND THALASSEMIA PATIENTS IN ISFAHAN IN 2005

 
 
Author(s):  NAGHAVI N.S., SAMIMIRAD K.*, SALEHI MANSOUR, SHANEHSAZZADEH M., HOURFAR H., NATEGH R.
 
* 
 
Abstract: 

Background and objective: Haemophilia and thalassemia patients are at risk of acquiring hepatitis C virus infection. The rate of HCV infection and risk factors were evaluated among anti-HCV positive haemophilia and thalassemia patients in Isfahan.
Material and Methods: Serum samples of 103 anti-HCY positive haemophiliacs and thalassemics were tested by nested RT-PCR.
Results: 60% and 58% of anti-HCV positive haemophiliacs and thalassemics were HCV RNA positive respectively. Positivity for HCV RNA had no correlation with the type of disease (haemophilia or thalassemia) and the mean age of the patients. The rate of HCV infection in patients received blood or blood products from Isfahan province were 20% of those who frequently received blood or blood products from Isfahan or other provinces. In haemophiliacs, the rate of positive HCV RNA was significantly higher in male than in the females (p<0.03). A 2.6 folds increased frequency of HCV RNA was observed in patients treated by interferon and ribavirin for one year compared to patients treated for a period of 4 to 6 months.
Conclusion: Our study reports a lower prevalence compared to western countries, where the widespread use of clotting factor concentrates began before the availability of inactivated products. Viral genotyping is necessary for effective treatment of infection and understanding the molecular epidemiology of HCV.

 
Keyword(s): HEPATITIS C VIRUS (HCV), HAEMOPHILIA, THALASSEMIA, TRANSFUSION
 
References: 
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