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Paper Information

Journal:   PHYSIOLOGY AND PHARMACOLOGY   WINTER 2009 , Volume 12 , Number 4; Page(s) 336 To 341.
 
Paper: 

ASSOCIATION BETWEEN TOBACCO SMOKE AND SERUM NITRIC OXIDE METABOLITES CONCENTRATION

 
 
Author(s):  GHASEMI ASGHAR, SEYD MORADI L., MOUMENAN A.A., ZAHEDIASL S.*
 
* ENDOCRINE PHYSIOLOGY LAB., ENDOCRINE RESEARCH CENTER, RESEARCH INSTITUTE FOR ENDOCRINE SCIENCES, SHAHID BEHESHTI UNIVERSITY (M.C.) TEHRAN, IRAN
 
Abstract: 

Introduction: Cigarette smoking affects nitric oxide production. The aim of this study was to determine associations between tobacco smoke and serum nitric oxide metabolites (NOx) concentration.
Methods: Serum NOx concentration was measured by the Griess method in 230 nonsmokers, 238 active, 196 passive and 29 waterpipe smokers. Subjects were selected from participants of Tehran Lipid and Glucose Study and blood samples were taken 12-14 h after overnight fasting. Mean NOx values were compared between groups by analysis of variance and p values less than 0.05 were considered significant.
Results: Serum NOx concentration was significantly higher in smokers (28.2±1.0
mmol/l) compared to passive (25.8±1.0 mmol/l) and nonsmokers (25.3±1.0 mmol/l) (p<0.05), while no significant difference was found in the level of NOx between passive and waterpipe smokers (29.0±1.1 mmol/l) compared to nonsmokers.
Conclusion: Serum NOx concentration is increased in active smokers, which may be involved in the development of vascular diseases.

 
Keyword(s): NITRIC OXIDE, WATERPIPE, CIGARETTE SMOKE, HUMAN
 
References: 
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