Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   SPRING 2009 , Volume 7 , Number SUPPL 2; Page(s) 0 To 0.
 
Paper: 

EFFECT OF KINDLING WITH PENTYLENETETRAZOL ON SEXUAL HORMONE AND SPERM OF MALE RATS

 
 
Author(s):  MEHRABINASAB E.*, KHAZAEI M.
 
* DEPARTMENT OF FERTILITY AND INFERTILITY, SCHOOL OF MEDICINE, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, IRAN
 
Abstract: 

Introduction: Epilepsy is a disorder of cerebral neuron function. Clinical studies suggest a relationship between epilepsy and Hypogonadism. The object of present work is to investigate recognition induced epilepsy effect by kindling with pentylenetetrazol (PTZ) on hormones and some reproductive parameters in male rat.
Materials and Methods: Adult male rat (NMRI strain) were divided in to control and kindling group. Kindling, was induced with 40 mg/kg PTZ with 48 hour interval by intraperitoneal injection. Each animal received 13 doses. At the end of thirteenth dose, animals were weighed and uthenaized with ether and blood were collected from heart for testosterone, prolactin and FSH, LH assay. In order to examination of motility and morphology of sperms, tissue samples from epidydimis was isolated and is minced in DMEM/F12 culture medium and incubated for 15 minutes then sperm morphology and motility were studied . Testis were isolated and weighted. Data were analyzed with T-test method.
Results: Kindling with PTZ decrease serum level of testosterone, LH and increaseprolactin. But there is no difference in serum level of FSH between two groups sperm motility in kindling group significantly decrease. There is no significant difference in testis weight, but degree of animal weight losses of kindling group was seen.
Conclusion: Kindling with PTZ with change Serum level of sexual hormones and decrease sperm motility so it exerts diminishing negative effect on reproduction.

 
Keyword(s): KINDLING, PTZ, RAT, FSH, LH, TESTOSTERONE, PROLACTIN
 
References: 
  • ندارد
 
  Yearly Visit 56
 
Latest on Blog
Enter SID Blog