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Paper Information

Journal:   TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)   JANUARY 2009 , Volume 66 , Number 10; Page(s) 734 To 739.
 
Paper: 

DETERMINATION OF CMV INFECTION IN CSF OF CHILDREN WITH MENINGOENCEPHALITIS: PCR METHOD

 
 
Author(s):  NOURBAKHSH SAMILEH*, TABATABAEI AZARDOKHT, PARVARESH M., TONEKABONI H.
 
* 8TH FLOOR HAZRAT RASOOL HOSPITAL, NIAYESH STREET, SATARKHAN AVENUE, RESEARCH CENTER OF PEDIATRIC INFECTIOUS DISEASES, TEHRAN, IRAN
 
Abstract: 

Background: In recent years, many ill cases with cytomegalovirus reactivation in nonimmuno compromised persons reported. Goal of study: to determine the CMV infection in cerebrospinal fluid of aseptic meningoencephalitis children hospitalized in Rasul & Mofid hospital (2005-2007).
Methods: In a cross sectional study 132 cases selected with simple sampling. CMVDNA in their Cerebro spinal fluids searched by qualitative PCR.
Results: The age range of the study patients was 5 month- 13 years, median age= 2
±3.7 years; 87(65.9%) male and 45 (34.1%) was female. The presenting signs and symptoms were convulsion 77(69.4%); meningitis 25 (18.8%), loss of consciousness 47(37%); neurologic defects 15.9%. DNA extrated in 11 cases. Mycoplasma- DNA in 2cases; DNA-CMV detected 2(1.5%). Positive DNA HSV found in 7(15.3%) of patients. DNAHSV type- 15.3% (7/132) cases. An infant 5 month age with developmental delay, microcephaly and recurrent convulsions. A 1 year girl with brain atrophy and progressive hydrocephaly with intracranial shunt.
Conclusions: Differentiation between herpes meningoencephalitis and other encephalopathy based on clinical signs in children is too difficult. CMV (1.5%) has lower rate than herpes simplex type-1 (5.7%). In addition to CMV and HSV1 all of herpes family viruses (varicella, herpes 6, 7, Epstein barr virus) could have role in children with meningoencephalitis. In recent years a sensitive, rapid, simple diagnostic test "Single tube Multiplex PCR" in cerebro spinal fluid recommend. Rapid diagnosis and faster treatment is necessary for decreasing mortality and morbidity in all of herpes meningoencephalitis cases.

 
Keyword(s): PCR (POLYMERASE CHANGE REACTION), CYTOMEGALOVIRUS (CMV), MENINGOENCEPHALITIS
 
References: 
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