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Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   WINTER 2008 , Volume 25 , Number 87; Page(s) 1 To 7.
 
Paper: 

EFFECT OF MELATONIN IN THE PREVENTION OF POSTOPERATIVE ADHESION FORMATION IN AN EXPERIMENTAL STUDY

 
 
Author(s):  MOVAHEDI MINOU*, HAJHASHEMI M., ADIBI SH.
 
* ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: Post operative adhesion formation is a very important clinical problem because of its complications such as pain, bowel obstruction, infertility and subsequent intra-operative complications. We aimed to investigate the effects of melatonin (ME), as an agent acting against free radicals, on the prevention of adhesion formation.
Methods: A number of 39 rats were randomly assigned into three groups of equal number. Serosal injury was created using a standard technique, one group received a single dose of intraperitoneal (IP) ME immediately after injury; a single dose of subcutaneous (SC) ME was given to the second group 30 minutes prior to surgery; but the control group did not received ME. All animals were re-operated 2 weeks after the surgery and the adhesion scores were determined by an examiner blinded to the under experiment groups.
Findings: The total score of adhesion reduced significantly in IP and SC groups in comparison to controls (p<0.01). The mean adhesion score in control group was 1.57 in IP, 1.34 in SC and 2.43 in controls.
Conclusion: This study showed that single dose ME therapy can be effective in the prevention of post operative adhesion formation. This finding may be a basis for future studies.

 
Keyword(s): ADHESION FORMATION, MELATONIN, PREVENTION, EXPERIMENTAL STUDY
 
References: 
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