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Paper Information

Journal:   IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY   FALL 2008 , Volume 20 , Number 3 (53); Page(s) 161 To 164.
 
Paper: 

LEUKOCYTE ADHESION DEFICIENCY SYNDROME AND REPORT OF THREE CASES

 
 
Author(s):  HAMEDI A.A.K.*, MOKHTARI N.A.
 
* DEPARTMENT OF PEDIATRIC MEDICINE, IMAM REZA HOSPITAL, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, IRAN
 
Abstract: 

Introduction: Leukocyte adhesion deficiency syndrome (LADS) is a rare inherited immunodeficiency in which the function of leukocytes, particularly the phagocytes are disturbed.
Case report: In the present sudy, we report three cases with LADS (2 male infants and 1 female child) who had a history of delay in separation of umbilical cord. One infant admitted for skin infection and two patients admitted in hospital following bacterial and fungal infections in nose and finger.All cases had a remarkable leukocytosis, neutrophilia and decreased of CD11 and CD18.
Conclusion: LADS is a congenital syndrome causes recurrent bacterial and fungal infections. Usually all patients have a history of delayed separation of umbilical cord.

 
Keyword(s): LEUKOCYTE ADHESION, PHAGOCYTE, INFECTION
 
References: 
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