Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS   FALL 2008 , Volume 24 , Number 3 (41); Page(s) 333 To 341.
 
Paper: 

THE EFFECTS OF HYDROALCOHOLIC EXTRACTS OF DILL (ANETHUM GRAVEOLENS L.) AND ARTICHOKE (CYNARA SCOLYMUS L.) AGAINST TYPE 1 DIABETES MELLITUS

 
 
Author(s):  AHMADI MAHMOUDABADI NARGOL*
 
* DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, ISFAHAN UNIVERSITY, IRAN
 
Abstract: 

This study investigated human type-1 diabetes mellitus in rats with use using alloxan monohydrate. Then, the effects of hydroalcoholic extracts of dill and artichoke on biochemical factors for example glucose, cholesterol, triglyceride, VLDL-C, HDL-C and LDL-C were studied and compared. 25 adult male rats, weighing about 200-250 gr, were used in five groups of five each. Rats in the control group, received physiological serum equal to injecting material volume. Rats in the second group (diabetic), induced diabetes with 120 mg/kgbw dose of alloxan monohydrate. Third group (diabetic + glibenclamide) received 0/5 mg/kgbw glibenclamide in addition to the similar treatment with second group. Rats in fourth and fifth groups first, became diabetic by alloxan monohydrate injection, then they received 300 mg/kgbw dill and artichoke hydroalcoholic extracts orderly. Prescribing materials in all groups was done as interaperitoneal injection. After last injection heart blood sampling was done, then concentration of serum factors was measured by enzymatic method. According to obtained results Anethum graveolens L. and Cynara scolymus L. extracts reduce the rate of glucose, cholesterol, triglyceride, VLDL-C and LDL-C than diabetic group significantly (P< ٠/05). Also HDL-C level was increased significantly (P< ٠/05). Results of study of serum factors expressed better function of dill extract compared to artichoke extract. The effect of extracts was similar to glybenclamide. Thus herbal drugs have lesser harmful side effects than chemical drugs, with further studies on clinical effect of extract, these plants can be used as an appropriate substitute for chemical drugs.

 
Keyword(s): DILL (ANETHUM GRAVEOLENS L.), ARTICHOKE (CYNARA SCOLYMUS L.), ALLOXAN MONOHYDRATE, TYPE-1 DIABETES MELLITUS
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 105
 
Latest on Blog
Enter SID Blog