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Paper Information

Journal:   RESEARCH ON SPORT SCIENCE   SUMMER 2008 , Volume 6 , Number 19; Page(s) 111 To 125.
 
Paper: 

EFFECT OF ACUTE SUPPLEMENTATION OF 500 MG VITAMIN C ON EXERCISE-INDUCED LIPID PEROXIDATION AND INFLAMMATION

 
 
Author(s):  NOKHOSTIN ROUHI B., RAHMANINIA FARHAD, BABAEI PARVIN, BOHLOULI SH.
 
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Abstract: 

Purpose: The aim of this study was to examine the effect of acute supplementation of 500 mg vitamin C on oxidative stress and inflammation after 30-min exercise at 75% Vo2max. Methods: Sixteen healthy male, unfamiliar with the exercise protocol, randomly received either antioxidant (AO) (500 mg vitamin C) or placebo (P) 2h before a 30-min treadmill run at 75% Vo2max. Plasma vitamin C concentration (VC) and Malondealdehyde (MDA) as oxidative stress marker using HPLC, Creatine Kinase (CK) as muscle damage marker using Autoanalzser, and Interleukin-6 (IL-6) as inflammation marker using ELISA, Were measured.
Results: ANOVA repeated measures with Bonferroni correction was used to compare results over the times and independent t-test was used to determine between groups differences. Vitamin C increased significantly 2h after supplementation, immediately and 2h after exercise in AO group (P<0.05).Serum CK, increased significantly after exercise in both groups (P<0.05) and decrease 24th after exercise only in OA group. Serum IL-6, increased significantly after exercise (P<0.05) and decrease 24th after exercise in both groups. MDA increased significantly after exercise in P group (P<o.05) but not in AO group (P>0.05).
Conclusion: The results indicate that 500 mg VC supplementation prevented muscle damage and exercise-induced oxidative stress but not inflammation in these subjects.

 
Keyword(s): FREE RADICALS, ANTIOXIDANT, CREATINE KINASE, MALONDEALDEHYDE, INTERLEUKIN-6
 
References: 
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