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Paper Information

Journal:   JOURNAL OF MEDICAL COUNCIL OF I.R.I.   SUMMER 2004 , Volume 22 , Number 2; Page(s) 116 To 121.
 
Paper: 

FAMILIAL AGGREGATION FOR MYOPIA AND ITS GENE-ENVIRONMENT INTERACTIONS

 
 
Author(s):  FOTOUHI A., HOLAKOUEI NAEINI KOUROSH, HASHEMI H.
 
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Abstract: 

Myopia is the most common refractive error involving a host of genetic and environmental causes but the precise contribution of these factors and their interactions are not known. The objective of this project is to examine familial relationships for myopia among siblings of myopic patients and the distributions of hereditary and environmental factors on it.
In this study, 602 (71.9%) siblings out of 838 invited siblings participated from 245 families. The participants aged 15 years and above, had myopia of at least 0.5 diopters in one or both eyes. We performed visual examinations and interviews for data on the manifest refraction, age, sex, ethnic, height, education and the amount of near works.
Odds ratios (OR) were used as a measure of familial aggregation and logistic regression with approach of second order Generalized Estimating Equations was fitted to control the passiblity of confounding factors.
Of the participants, 466 (77.3%) were myopic. There was a strong evidence for a familial aggregation, as the odds ratio for myopia among family members was 5.75 (95% CI=2.97-11.14, P<0.001).Among other variables, none showed a significant association with myopia; after adjustment for these factors, the familial aggregation persisted with OR=5.22 (95% CI=2.43-11.24,P<0.001).
In conclusion, we found an obvious familial aggregation for myopia, and this association remained after adjusting for other confounding variables. Further studies especially in population are needed to evaluate the effect of other environmental variables and to quantify their respective effects.

 
Keyword(s): MYOPIA, FAMILIAL AGGREGATION, INTERACTION, ENVIRONMENTAL FACTORS
 
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