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Paper Information

Journal:   MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY   SPRING 2008 , Volume 18 , Number 1 (51); Page(s) 7 To 11.
 
Paper: 

INTERACTION OF α2-ADRENERGIC SYSTEM AND CAFFEINE ON PASSIVE AVOIDANCE LEARNING IN MALE WISTAR RATS

 
 
Author(s):  YAGHMAEI PARICHEHR*, ORYAN SHAHRBANOU, HOJATI ZAHRA, JAVADI HAMID REZA
 
* DEPARTMENT OF BIOLOGY, ISLAMIC AZAD UNIVERSITY, SCIENCE AND RESEARCH CAMPUS, TEHRAN, IRAN
 
Abstract: 

Background: There are numerous studies on the effects of caffeine on memory and learning. The activation of a2-adrenoreceptors has been reported to impair memory functions in both rats and humans. In this study, interaction of a2-adrenergic system and caffeine on memory and learning was evaluated.
Materials and methods: In this experimental study, 90 wistar rats assigned into six groups of fifteen. Rats received yohimbine (4, 6, 8, 10
mg), as a a2-adrenergic antagonist, clonidine (2, 4, 6mg), as a a2-adrenergic agonist, and caffeine (10, 20, 30mg). The cannula was implanted into the right lateral ventricle of all rats with steriotaxi method. Then, they were trained in shuttlebox. Post-training intracerebroventricular (ICV) injection was carried out in all experiments and optimum doses were identified.
Results: Caffeine and yohimbine fostered memory and learning (p<0.001), while clonidine diminished these abilities compared to saline injection (p<0.05). Co-administration of the optimum doses of clonidine and yohimbine showed statistically significant reduction in the time of step-through latency (p<0.05). Instead, co-administration of clonidine and caffeine revealed no significant increase in the time of step-through latency (NS).
Conclusion: It is concluded that yohimbine and caffeine, unlike clonidine, increase memory.

 
Keyword(s): CAFFEINE, YOHIMBINE, CLONIDINE, α2-ADRENERGIC SYSTEM, MEMORY, LEARNING
 
References: 
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