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Paper Information

Journal:   JOURNAL OF VETERINARY RESEARCH   2000 , Volume 55 , Number 2; Page(s) 1 To 8.
 
Paper: 

EXPERIMENTAL STUDY OF HEALING EFFED OF SODIUM HYALURONATE IN DEEP DIGITAL FLEXOR TENDON INJURY IN HORSES

 
 
Author(s):  SARDARI K., NOUROUZIAN I., MOVASAGHI A.R., SOROURI SARANG, VEN VEIREN R.
 
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Abstract: 

Sodium hyaluronate reduce adhesions after tendon repair In rodents and dogs, and has been no reports in people. To evaluate its effect on tendon healing in horses and to compare it with compound of similar viscoelastic properties, a study was performed on 8 horses, using a model of Zig Zag splitting injury in DDFT. Eight clinically normal horses were randomly divided into 2 groups under general anaesthesia tendon splitting was performed in ZigZag form in DDFF in one forelimb in all horses. ulterasonographic examination after tendon splitting was performed and confirmed the same injuries in all tendons. Group A horses had sodium hyaluronate (NaH) gel (10 mg / ml) into the site of injury every other days for five successive days. Group b horses had methylcellulose (MeS) gel injection at the same site. Serial ultrasonographic examination was performed in 2 groups at 7, 14, 21, 28 and 60 days after last intralesional injection. Horse were euthanatized after 14 weeks of stall rest ultrasonographic evaluation revealed improved tendon healing after NaH  injection (p<0.05).
histological, the DDFT from the NaH treated limbs had reduced inflammatory cells infiltration, improved tendon structure and less intertendinous hemorrhage, treatment with MeS had no significant effect on tendon healing. Soudium hyaluronate administered intralesionally appears to have a pharmaceutically beneficial action in this model of tendonitis.

 
Keyword(s): SODIUM HYALUROANTE, DEEP DIGTAL FLEXOR, TENDON, HEALING, HORSE
 
References: 
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