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Paper Information

Journal:   MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)   MAY 2000 , Volume 14 , Number 1; Page(s) 83 To 86.
 
Paper: 

PREVENTIVE EFFECTS OF VITAMIN B12 AND FOLIC. ACID IN METHANOL-INDUCED RETINOPATHY IN AN ANIMAL MODEL

 
 
Author(s):  SHAHRIARI H.A., HOSSEINIRAD A.
 
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Abstract: 

In order to identify the effects of vitamin B12 and folic acid in reducing methanol induced retinopathy, ERG waves were compared before and after methanol intoxication in rabbits. In this study 34 rabbits were divided in to 4 groups. All groups received 4 g/kg of methanol intraperitoneally. In addition, the second, third and fourth groups received vitamin B12 injection, oral folic acid and a mixture of vitamin B12 and folic acid, respectively.
Baseline ERGs were recorded for all rabbits prior to intoxication and then second ERGs were taken 48-72 hours following methanol toxicity. Compared to baseline ERGs; a severe reduction in the b-wave amplitude as well as reduction in the oscillatory potential were noticed. Among all groups, the first group had the most and the fourth group had the least decrease in b-wave amplitude as well as oscillatory potential. It is therefore believed that vitamin B12 has a synergistic effect with folic acid in attenuating ophthalmic toxicity of methanol in rabbits. Further studies are needed to evaluate these effects in humans.

 
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