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Paper Information

Journal:   JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES   FALL 2001 , Volume 8 , Number 4; Page(s) 179 To 184.
 
Paper: 

CALCIUM AND PHOSPHORUS METABOLISM DURING METHYLPREDNISOLONE PUIS THERAPY

 
 
Author(s):  SOVEYD MAHMOUD, AFLAKI E.
 
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Abstract: 

Intravenous glucocomcoid pulse therapy is a common treatment for immunologically origin diseases but it cannot be considered a completely benign treatment. The effects of long term administration of glucocorticoids on calcium and phosphorus metabolism are well known, but less is known about the effect of pulse therapy. The purpose of this study was to investigate the effect of methylprednisolone pulse therapy on serum and uninary calcium and phosphorus and serum parathormone. In this prospective study 40 patients who received methylprednisolone pulse therapy for different reasons were investigated. Patients with renal insufficiency and those taking medications affecting calcium and phosphorus metabolism were excluded. Serum calcium, phosphorus, parathormone, creatininand urinary calcium, phosphous, and creatinine were measured before pulse therapy and in three consecutive days after treatment. This intervention had no effect on serum calcium, parathonnone and urinary calcium. Serum phosphorus decreased with a nadir on the second day and urinary phosphous increased. It was concluded that glucocorticoid pulse therapy directly increases renal phosphorus excretion, but calcium metabolism is not disturbed.

 
Keyword(s): GLUCOCRTICOID, METHYLPREDNISOLONE PULSE THERAPY, CALCIUM, PHOSPHORUS, PARATHONNONE
 
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