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Paper Information

Journal:   JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES   WINTER 2008 , Volume 6 , Number 4 (25); Page(s) 291 To 298.
 
Paper: 

INVESTIGATION OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY IN RAFSANJAN, AUTUMN 2004

 
 
Author(s):  ALIDALAKI S., NEGAHBAN BONABI T., HOULAKOUEI MARZIEH, SAYADI ANARI AHMAD REZA, AHMADI KOHANALI JAFAR, ESMAEILZADEH MASOUMEH, ASADI KARAM GH.R.*
 
* DEPT. OF BIOCHEMISTRY AND BIOPHYSICS, UNIVERSITY OF MEDICAL SCIENCES, RAFSANJAN, IRAN
 
Abstract: 

Background and Objective: G6PD (Glucose -6- phosphate dehydrogenase) is the first enzyme of pentose phosphate pathway, which plays an important role in NADPH production. NADPH is necessary for preventing of cell oxidation. Deficiency of this enzyme led to hemolysis in some situations. This study has been done to determine the prevalence of G6PD deficiency and its relation with sex, blood group, Rh and familial history of new born in Rafsanjan.
Materials and methods: In this cross sectional study blood sample was collected on a special filter paper and the activity of G6PD was measured by fluorescent spot test. The data were analyzed by Chi-square and Fisher exact test. Significance was defined as p<0.05.
Results: There were 523 boys and 495 girls out of 1018 alive newborns. The G6PD deficiency was 5.7% for boys, 4.2% for girls and 5% for all the alive newborns. No significant relation, between prevalence of G6PD deficiency and blood group, sex, familial history and Rh were found.
Conclusion: The G6PD deficiency prevalence in Rafsanjan is less than other parts of Iran and the worlds (10%-14.9%). Given the screening test is cheep and easy it is suggested to perform this test at birth to differentiate the relatively or completely deficient sample to prevent of health problems.

 
Keyword(s): GLUCOSE -6- PHOSPHATE DEHDYROGENASE, NEWBORNS SCREENING, NEWBORNS, FAUVISM
 
References: 
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