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Paper Information

Journal:   CELL JOURNAL (YAKHTEH)   2008 , Volume 10 , Number SUPPLEMENT 1; Page(s) 55 To 56.
 
Paper: 

TLR9 IN CILIATED CELLS OF HUMAN FALLOPIAN TUBE

 
 
Author(s):  GHASEMI N.*, AFLATOUNIAN A., AFLATOUNIAN R.
 
* YAZD IVF CENTRE, GENETIC DEPARTMENT, YAZD, IRAN
 
Abstract: 

Objective: The innate immune system evolved to detect and respond to infection. Several families of receptors detect highly conserved pathogen-expressed molecules that are not expressed by or accessible in host cells. One of the best understood of these families is the TLR family of molecules, of which ten have been identified in humans. Each TLR binds to one or more distinct pathogenexpressed molecules and can function as an "alarm signal" for the immune system, initiating appropriate host immune defenses. TLR9 seems to evolve in detection of the unmethylated CpG dinucleotides that are relatively common in bacterial and viral genomic DNAs but are uncommon in vertebrate genomes and, if present, are highly methylated.
Materials and Methods: Normal fallopian tubes were detected by H&E staining, which blocks obtained from patients undergoing abdominal hysterectomy for benign gynecological conditions. Using immunohistochemistry techniques, distribution of TLR9 was studied in blocks of the fallopian tubes.
Results: Result showed TLR9 was present in epithelium especially in ciliated cell of fallopian tube intensely. The intensity of staining was not equal in cases.
Conclusion: Regulation of TLR9 expression and signaling may play an important role in the control of responses to luminal microorganisms. TLR9 stimulation innate immunity, which could make good defense against infection or tumor.

 
Keyword(s): CLILIATED CELL, FALLOPIAN TUBE, TLR9, INNATE IMMUNITY
 
References: 
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