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Paper Information

Journal:   FEYZ   SUMMER 2002 , Volume 6 , Number 22; Page(s) 1 To 6.
 
Paper: 

EFFECT OF CADMIUM CHLORIDE ON COCHLEAR DEVELOPMENT IN MOUSE FETUS

 
 
Author(s):  ROUZBEHI A.A.*, ATLASI M.A.
 
* DEPARTMENT OF ANATOMY, YASOUJ UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Background: Cadmium is an essential component of industrial and non-industrial materials including foods, water, drinks, and cigarettes. Reports have shown the Teratogenic effects of cadmium, thus the present study was carried out with the aim of determining the effects cadmium chloride on cochlear development in male mouse fetus.
Materials and methods: In this experimental study 30 male mouse fetuses of balb/ c race were included Samples were divided in-three groups of control. Experiment I, and Experiment II. Experiment groups have received cadmium chloride with the dosage of 3mg/kg and 5mg/kg intraperitonealy at the 9th day pregnancy, respectively. The control group received distilled water. Six days later, mice were killed ether and their fetuses were removed and kept fixative. Finally, specimens were prepared and stained by H&E. Results were analyzed using ANOVA and sche.ffe tests.
Results: Cochleal surface was significantly reduced in Experiments groups comparing to the control (p<0.05), meanwhile, the spiral ganglion surface was significantly reduced, top (p<0.01 and p<0.003). The ecochleal diameter has not differed among the groups (NS). The organ of corti in Experiment II group was smaller than that of control group (p<0.02).
Conclusion: Cadmium chloride can cause degenerative changes on cochlear development al mouse fetus. Further studies regarding the effects of cadmium chloride on neural the deformity and hearing dysfunction are strongly recommended.

 
Keyword(s): CADMIUM CHLORIDE, COCHLEA, TERATOGEN
 
References: 
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