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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   WINTER 2008 , Volume 10 , Number 4 (36); Page(s) 229 To 232.
 
Paper: 

EFFECT OF PORTULACA OLERACEAE L. EXTRACTS ON THE MORPHINE DEPENDENCE IN MICE

 
 
Author(s):  KARIMI GH.R.*, ZIAEI T., NAZARI AZAM
 
* DEPARTMENT OF PHARMACODYNAMY AND TOXICOLOGY, SCHOOL OF PHARMACY AND MEDICAL RESEARCH TOXICOLOGY CENTER MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Objective: This study was initiated to investigate the effect of Portulaca oleraceae on morphine dependence in mice.
Materials and Methods: Dependence was induced using the subcutaneous injections of morphine for 3 days. On the day 4, morphine injected 2 h prior to intraperitoneal injection of naloxone. The plant extracts ethanolic or aqueous administered 0.5 h before the final dose of morphine. The number of jumping during the 30 min period after naloxone injection was considered as a measure of withdrawal syndrome.
Results: Both extracts reduced the jumping episodes dose-dependently. The maximum effect was observed at doses of 0.28 g/kg and 1.4 g/kg for the aqueous and ethanolic extracts, respectively. Clonidine and extracts decreased the total activity in locomotion test.
Conclusion: These findings indicated that Portulacea oleraceae extracts can decrease morphine dependence in mice.

 
Keyword(s): MORPHINE, DEPENDENCE, PORTULACA OLERACEAE
 
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