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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   WINTER 2008 , Volume 10 , Number 4 (36); Page(s) 206 To 215.
 
Paper: 

AN INVESTIGATION OF THE RELATIONSHIP BETWEEN SERUM VITAMIN E STATUS AND CORONARY RISK FACTORS IN DYSLIPIDAEMIC PATIENTS

 
 
Author(s):  GHAYOUR MOBARHAN M.*, SAHEBKAR A.H., STARKEY B., LIVINGSTONE C., WANG T., LAMB D., FERNS G.
 
* DEPARTMENT OF NUTRITION AND BIOCHEMISTRY, FACULTY OF MEDICINE, MUMS, MASHHAD, IRAN 9138813944
 
Abstract: 

Objective: Vitamin E is a major lipid-soluble antioxidant. It has been demonstrated that vitamin E supplementation has a beneficial effect against coronary heart disease (CHD). This study to investigate the effects of coronary risk factors on serum vitamin E status in patients with dyslipidaemia.
Materials and Methods: This tertiary care hospital; case - control study was comprised 237 dyslipidaemic patients and 135 healthy individuals recruited from university and hospital employees. Serum vitamin E concentration was measured using high performance liquid chromatography (HPLC).
Results: Compared to the healthy individuals, the dyslipidaemic patients had higher serum vitamin E (p<0.001), but serum vitamin E / total cholesterol ratio did not differ between patients and healthy controls (p>0.05). Serum vitamin E did not differ between subcategories of dyslipidaemic patients with and without coronary risk factors (p>0.05), but Serum vitamin E / total cholesterol ratio was higher in patients with established coronary heart disease (p<0.01), hypertriglyceridaemia (p<0.05) and metabolic syndrome (p<0.05). In the patients there was not a strong association between serum vitamin E or serum vitamin E / total cholesterol ratio and coronary risk factors except for the serum cholesterol.
Conclusion: Serum vitamin E or vitamin E / total cholesterol ratio is not associated with the risk of coronary heart disease. Therefore, higher serum vitamin E or vitamin E / total cholesterol ratio doesn’t seem to have a preventive role against coronary heart disease.

 
Keyword(s): CHOLESTEROL, CORONARY HEART DISEASE, DYSLIPIDAEMIA, METABOLIC SYNDROME, MULTIPLE REGRESSION ANALYSIS, VITAMIN E
 
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