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Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   FALL 2007 , Volume 5 , Number 4; Page(s) 187 To 190.
 
Paper: 

COMPARING THE LEVELS OF BHCG, PROGESTERONE AND ESTRADIOL BETWEEN ECTOPIC PREGNANCY AND NORMAL INTRAUTERINE PREGNANCY

 
 
Author(s):  GHARA BAGHI P.*, ABD ELAHIFARD S., GHARABAGHI MANIZHEH, NOURI MOHAMMAD
 
* DEPARTMENT OF OBSTETRICS AND GYNECOLOGY, ALZAHRA HOSPITAL, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Background: The value of serial measurement of serum b subunit of human chorionic gonadotropin (bHCG) and ultrasonography in the early diagnosis of ectopic pregnancy has well established.
Objective: The objective of this study was to explore the diagnostic value of raising level of serum
bHCG, single measurement of progesterone (P) and estradiol (E2) in early diagnosis of ectopic pregnancy.
Materials and Methods: Serum levels of
bHCG and estradiol were measured by Radio Immuno Sorbent Assay (RIA) and progesterone level was measured by Enzyme Linked Immuno Sorbent Assay (ELISA) techniques in 43 symptomatic women with ectopic pregnancy and 42 women with normal intrauterine pregnancy in Alzahra Hospital, Tabriz, Iran. These values were compared by T-test. By determining cut-off levels of these parameters the efficiency and sensitivity of them in prediction of ectopic pregnancy was estimated.
Results: The mean serum levels of
bHCG, estradiol and progesterone in patients with ectopic pregnancies (940±552 mlu/ml, 593±237 pg/ml, 5.83±3.41 ng/ml, respectively) were significantly lower than these levels in normal intrauterine pregnancies (4620±2030 mlu/ml, 1627±435 pg/ml, 24.8±6.08 ng/ml, respectively). The average rate of bHCG rising was 8.2% for 24 hours in patients with ectopic pregnancy (EP) and 32.8% in normal intrauterine pregnancies (NIUP).
Conclusions In this study single measurement of serum progesterone level has the greatest sensitivity (100%) and specificity (98%) in the diagnosis of ectopic pregnancy.

 
Keyword(s): BETA SUBUNIT OF HUMAN CHORIONIC GONADOTROPIN (BHCG), ESTRADIOL, PROGESTERONE, ECTOPIC PREGNANCY, NORMAL INTRAUTERINE PREGNANCY
 
References: 
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